EFFICACY OF SOFOSBUVIR AS TREATMENT FOR YELLOW FEVER: PROTOCOL FOR A RANDOMISED CONTROLLED TRIAL IN BRAZIL (SOFFA STUDY)

Efficacy of sofosbuvir as treatment for yellow fever: protocol for a randomised controlled trial in Brazil (SOFFA study)

Introduction An ongoing outbreak of yellow fever (YF) has been reported in Brazil with 1261 confirmed cases and 409 deaths since July 2017.To date, there is no specific treatment available for YF.Recently Shorts published papers describing in vitro and animal models suggest a potential effect of antiviral drugs (approved for the treatment of hepati

read more

Imagery rehearsal therapy and mianserin for trauma-affected refugees: Follow-up of a randomized controlled trial

Introduction: In order to identify the efficacy Hand Grips of treatment interventions for trauma-affected refugees follow-up studies are highly warranted.Hence, the overall aim of this study was to examine the effi-cacy of sleep-enhancing treatment, IRT and mianserin, in a sample of 219 trauma-affected refugees at six-month follow-up post-treatment

read more

Numerical Calculation Analysis and Characteristic Research on Windage Loss of Oil-Jet Lubricated Aviation Gear Pair

The VOF (volume of fluid) multiphase transient simulation model of the windage loss of the gear pair under oil-jet lubrication was carried out by using the dynamic mesh technology with the powerful parallel computing capabilities of the Super Cloud Computing Center.Firstly, a two-phase (oil-gas) turbulence numerical model was established in the pro

read more

Nodule inception directly targets NF-Y subunit genes to regulate essential processes of root nodule development in Lotus japonicus.

The interactions of legumes with symbiotic nitrogen-fixing bacteria cause the formation of specialized lateral root organs called root nodules.It has been postulated that this root nodule symbiosis system has recruited factors that act in early signaling pathways (common SYM genes) partly from the ancestral mycorrhizal symbiosis.However, the origin

read more